Review Article Diabetic neuropathy (DN) is a widespread disabling disorder comprising peripheral nerves’ damage.DNdevelops on a background of hyperglycemia and an entangled metabolic imbalance, mainly oxidative stress. The majority of related pathways like polyol, advanced glycation end products, poly-ADP-ribose polymerase, hexosamine, and protein kinase c all originated from initial [...]
Natalia Vallianou, Angelos Evangelopoulos and Pavlos Koutalas Abstract Diabetic neuropathy presents a major public health problem. It is defined by the symptoms and signs of peripheral nerve dysfunction in diabetic patients, in whom other causes of neuropathy have been excluded. Pathogenetic mechanisms that have been implicated in diabetic neuropathy [...]
Clinical Study 1. Introduction Diabetes affects more than 300 million individuals in the world with significant morbidity and mortality worldwide [1]. In the United States, it has been estimated that the incidence is about 1 million new cases per year [2]. People with diabetes are at high risk of [...]
Abstract Objective: To evaluate the effects and safety of 300–600 mg a-lipoic acid (ALA) given i.v. for diabetic peripheral neuropathy (DPN). Methods: We searched the databases of Medline, Embase, and Cochrane central register of Controlled Trials and Chinese biological medicine for clinical trials of ALA in the treatment of [...]
Abstract Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age. How do the biochemical properties [...]
A b s t r a c t Background: Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated. Methods: Systematic literature review. The databases MEDLINE and EMBASE were searched [...]
