As part of ongoing clinical research, a scientific research protocol was conducted at the University of Ioannina (2nd Department of Internal Medicine), investigating the association between plasma vitamin D levels and risk factors for cardiovascular events in adolescents and adults.

The study, titled
“Association of Vitamin D Levels with Risk Factors and Drug Use for Cardiovascular Disease in Adolescents and Adults,”
focused on evaluating the effects of oral vitamin D supplementation on metabolic parameters in individuals diagnosed with metabolic syndrome.

The vitamin D supplement used in the study was Vitamin D 1000 IU by Lamberts®, administered at a daily dose of 2000 IU.

One of the metabolic parameters assessed was the level of 8-isoprostanes in urine, a well-established biomarker of oxidative stress, measured before and after vitamin D supplementation.

The results were particularly noteworthy, as vitamin D administration was associated with a reduction in urinary 8-isoprostane levels, indicating a decrease in oxidative stress among participants with metabolic syndrome.

The findings were presented at the 8th Panhellenic Conference on Free Radicals and Oxidative Stress, held in Thessaloniki from 12–14 October 2012, where the study received the 1st Prize Award from the Hellenic Society of Free Radicals and Oxidative Stress, in recognition of its scientific contribution.