Prevention of age-related macular degeneration

Abstract Age-related macular degeneration (AMD) is one of the leading causes of blindness in the developed world. Although effective treatment modalities such as anti-VEGF treatment have been developed for neovascular AMD, there is still no effective treatment for geographical atrophy, and therefore the most cost-effective management of AMD is [...]

2021-04-06T17:16:05+00:00 Μάρτιος 15, 2017|

Micronutrients in Age-Related Macular Degeneration

Abstract: Several lines of evidence from in vitro and in vivo studies suggest that specific micronutrients may have beneficial effects in age-related macular degeneration (AMD). Such effects appear to be complex and may include filtering short wavelength light and attenuating oxidative and inflammatory damage as well as other structural [...]

2021-04-06T17:20:11+00:00 Μάρτιος 15, 2017|

The Role of Lutein in Eye-Related Disease

Abstract: The lens and retina of the human eye are exposed constantly to light and oxygen. In situ phototransduction and oxidative phosphorylation within photoreceptors produces a high level of phototoxic and oxidative related stress. Within the eye, the carotenoids lutein and zeaxanthin are present in high concentrations in contrast [...]

2021-04-06T17:21:23+00:00 Μάρτιος 15, 2017|

Dry Age-Related Macular Degeneration: Mechanisms, Therapeutic Targets, and Imaging

Age-related macular degeneration is the leading cause of irreversible visual dysfunction in individuals over 65 in Western Society. Patients with AMD are classified as having early stage disease (early AMD), in which visual function is affected, or late AMD (generally characterized as either ‘‘wet’’ neovascular AMD, ‘‘dry’’ atrophic AMD [...]

2021-04-06T17:22:26+00:00 Μάρτιος 15, 2017|

Clinical Trial:Secondary Analyses of the Effects of Lutein/Zeaxanthin on Age-Related Macular Degeneration Progression AREDS2 Report No. 3

ImportanceThe Age-Related Eye Disease Study (AREDS) formulation for the treatment of age-related macular degeneration (AMD) contains vitamin C, vitamin E, beta carotene, and zinc with copper. The Age-Related Eye Disease Study 2 (AREDS2) assessed the value of substituting lutein/zeaxanthin in the AREDS formulation because of the demonstrated risk for [...]

2021-04-06T19:09:55+00:00 Μάρτιος 14, 2017|