Aims: To compare the efficacy of sublingual and oral administration of 500mg of cobalamin in subjects with cobalamin deficiency. Materials and results: Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to receive one tablet daily of 500mg cobalamin sublingually or orally, [...]
1. Introduction Lactose is the main sugar in milk and therefore the main energy source for the newborn. Milk contains 4,8% lactose [1]. Lactose is a disaccharide consisting out of glucose and galactose. In normal physiological conditions lactose is hydrolyzed by lactase also known as lactasephlorizin hydrolase and under [...]
Abstract: Because the human gut microbiota can play a major role in host health, there is currently some interest in the manipulation of the composition of the gut flora towards a potentially more remedial community. Attempts have been made to increase bacterial groups such as Bifidobacterium and Lactobacillus that [...]
Abstract: Proton pump inhibitors (PPIs) remain the superior choice worldwide in antisecretory therapy in the evidence-based treatment of upper gastrointestinal disorders including gastroesophageal reflux disease, erosive esophagitis, dyspepsia and peptic ulcer disease. PPI overutilization in ambulatory care settings is often a result of failure to re-evaluate the need for [...]
American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults The goal of this Consensus Statement is to help primary care practitioners achieve adequate vitamin D intake from all sources in their older patients, with the goal of reducing falls and fall-related injuries. The workgroup graded the quality [...]
Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid accumulation in the liver, is the hepatic manifestation of insulin resistance and the metabolic syndrome. Due to the epidemics of obesity, NAFLD is rapidly becoming the leading cause of altered liver enzymes in Western countries. NAFLD encompasses a wide spectrum [...]
Abstract Objective: To evaluate the effects and safety of 300–600 mg a-lipoic acid (ALA) given i.v. for diabetic peripheral neuropathy (DPN). Methods: We searched the databases of Medline, Embase, and Cochrane central register of Controlled Trials and Chinese biological medicine for clinical trials of ALA in the treatment of [...]
Abstract Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age. How do the biochemical properties [...]
A b s t r a c t Background: Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated. Methods: Systematic literature review. The databases MEDLINE and EMBASE were searched [...]
Abdulwahab Barakat • Ranjita Shegokar • Michael Dittgen • Rainer H. Muller Received: 12 July 2013 / Accepted: 21 September 2013 / Published online: 4 October 2013 The Korean Society of Pharmaceutical Sciences and Technology 2013 Abstract Coenzyme Q10 (Q10) has a poor bioavailability due to its very low [...]
